Analysis of mutations leading to para-aminosalicylic acid resistance in Mycobacterium tuberculosis
Analysis of mutations leading to para-aminosalicylic acid resistance in Mycobacterium tuberculosis
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Thymidylate synthase A (ThyA) is the key enzyme involved in the folate pathway in
Mycobacterium tuberculosis
. Mutation of key residues of ThyA enzyme which are involved in interaction with substrate 2′-deoxyuridine-5′-monophosphate (dUMP), cofactor 5,10-methylenetetrahydrofolate (MTHF), and catalytic site have caused
para
-aminosalicyl...
Alternative Titles
Full title
Analysis of mutations leading to para-aminosalicylic acid resistance in Mycobacterium tuberculosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6754364
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6754364
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-48940-5
