SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We report here a SuFEx-enabled, agnostic approach for the discovery and optimization of covalent inhibitors of human neutrophil elastase (hNE). Evaluation of our ever-growing collection of SuFExable compounds toward various biological assays unexpectedly revealed...
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Full title
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6754619
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6754619
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1909972116
