NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The transcription factor NRF2 is a master regulator of cellular antioxidant and detoxification responses, but it also regulates other processes such as autophagy and pluripotency. In human embryonic stem cells (hESCs), NRF2 antagonizes neuroectoderm differentiation, which only occurs after NRF2 is repressed via a Primary Cilia-Autophagy-NRF2 (PAN)...
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Full title
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6761261
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6761261
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-50356-0
