PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocyto...
PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The metabolic signatures of cancer cells are often associated with elevated glycolysis. Pharmacological (PFK158 treatment) and genetic inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a critical control point in the glycolytic pathway, decreases glucose uptake, ATP production, and lactate dehydrogenase activity and arre...
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PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6764980
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6764980
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-019-1916-3
