An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificit...
An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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TRiC/CCT assists the folding of ∼10% of cytosolic proteins through an ATP-driven conformational cycle and is essential in maintaining protein homeostasis. Here, we determined an ensemble of cryo-electron microscopy (cryo-EM) structures of yeast TRiC at various nucleotide concentrations, with 4 open-state maps resolved at near-atomic resolutions, an...
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An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6765261
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6765261
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1903976116
