Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunctio...
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model
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Berlin/Heidelberg: Springer Berlin Heidelberg
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Language
English
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Berlin/Heidelberg: Springer Berlin Heidelberg
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Contents
Parkinson’s disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between α-synuclein aggregates and PD is not well understood. We generated a new transgenic mouse line (MI2) expressing human, aggregation-prone truncated 1...
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Full title
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6778064
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6778064
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ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-019-02023-x
