SLC19A1 transports immunoreactive cyclic dinucleotides
SLC19A1 transports immunoreactive cyclic dinucleotides
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Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage
1
,
2
. Cytosolic DNA triggers immune responses by activating the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway
3
. The binding of DNA to cGAS activates its enzymatic...
Alternative Titles
Full title
SLC19A1 transports immunoreactive cyclic dinucleotides
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6785039
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6785039
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1553-0
