SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle c...
SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints
About this item
Full title
Author / Creator
Dong, Yunzhu , Zhao, Xinghui , Feng, Xiaomin , Zhou, Yile , Yan, Xiaomei , Zhang, Ya , Bu, Jiachen , Zhan, Di , Hayashi, Yoshihiro , Zhang, Yue , Xu, Zefeng , Huang, Rui , Wang, Jieyu , Zhao, Taoran , Xiao, Zhijian , Ju, Zhenyu , Andreassen, Paul R. , Wang, Qian-fei , Chen, Wei and Huang, Gang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
SETD2
, an epigenetic tumor suppressor, is frequently mutated in MLL-rearranged (MLLr) leukemia and relapsed acute leukemia (AL). To clarify the impact of
SETD2
mutations on chemotherapy sensitivity in MLLr leukemia, two loss-of-function (LOF)
Setd2-mutant
alleles (
Setd2
F2478L/WT
or
Setd2
Ex6-KO/WT
) were generate...
Alternative Titles
Full title
SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6785365
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6785365
Other Identifiers
ISSN
0887-6924,1476-5551
E-ISSN
1476-5551
DOI
10.1038/s41375-019-0456-2
