Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial c...
Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The DNA-damaging compound cisplatin is broadly employed for cancer chemotherapy. The mutagenic effects of cisplatin on cancer cell genomes are poorly studied and might even contribute to drug resistance. We have therefore analyzed mutations and chromosomal alterations in four cisplatin-resistant bladder cancer cell lines (LTTs) by whole-exome-seque...
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Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6785536
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6785536
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-50891-w
