Cell division rates decrease with age, providing a potential explanation for the age-dependent decel...
Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence
About this item
Full title
Author / Creator
Tomasetti, Cristian , Poling, Justin , Roberts, Nicholas J. , London, Nyall R. , Pittman, Meredith E. , Haffner, Michael C. , Rizzo, Anthony , Baras, Alex , Karim, Baktiar , Kim, Antonio , Heaphy, Christopher M. , Meeker, Alan K. , Hruban, Ralph H. , Iacobuzio-Donahue, Christine A. and Vogelstein, Bert
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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More information
Scope and Contents
Contents
A new evaluation of previously published data suggested to us that the accumulation of mutations might slow, rather than increase, as individuals age. To explain this unexpected finding, we hypothesized that normal stem cell division rates might decrease as we age. To test this hypothesis, we evaluated cell division rates in the epithelium of human...
Alternative Titles
Full title
Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6789572
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6789572
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1905722116
