Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy
Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
MYCN
-amplified (MNA) neuroblastoma is an aggressive neural crest-derived pediatric cancer. However, MYCN is indispensable for development and transcriptionally regulates extensive network of genes. Integrating anti-MYCN ChIP-seq and gene expression profiles of neuroblastoma patients revealed the metabolic enzymes,
MTHFD2
and
PAICS
,...
Alternative Titles
Full title
Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6797810
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6797810
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-019-2033-z
