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EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells

EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6805914

EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells

About this item

Full title

EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells

Publisher

London: Nature Publishing Group UK

Journal title

Cell death & disease, 2019-10, Vol.10 (11), p.801-14, Article 801

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The EPHB4 receptor is implicated in the development of several epithelial tumors and is a promising therapeutic target, including in prostate tumors in which EPHB4 is overexpressed and promotes tumorigenicity. Here, we show that high expression of EPHB4 correlated with poor survival in prostate cancer patients and EPHB4 inhibition induced cell deat...

Alternative Titles

Full title

EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6805914

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6805914

Other Identifiers

ISSN

2041-4889

E-ISSN

2041-4889

DOI

10.1038/s41419-019-2042-y

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