A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau:...
A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice
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Author / Creator
Hovakimyan, Armine , Antonyan, Tatevik , Shabestari, Sepideh Kiani , Svystun, Olga , Chailyan, Gor , Coburn, Morgan A. , Carlen-Jones, William , Petrushina, Irina , Chadarevian, Jean Paul , Zagorski, Karen , Petrovsky, Nikolai , Cribbs, David H. , Agadjanyan, Michael G. , Ghochikyan, Anahit and Davtyan, Hayk
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Pathological tau correlates well with cognitive impairments in Alzheimer’s disease (AD) patients and therefore represents a promising target for immunotherapy. Targeting an appropriate B cell epitope in pathological tau could in theory produce an effective reduction of pathology without disrupting the function of normal native tau. Recent data demo...
Alternative Titles
Full title
A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6820729
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6820729
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-51809-2
