The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro
The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro
About this item
Full title
Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Exposure to aristolochic acid (AA) is associated with human nephropathy and urothelial cancer. The tumour suppressor
TP53
is a critical gene in carcinogenesis and frequently mutated in AA-induced urothelial tumours. We investigated the impact of p53 on AAI-induced nephrotoxicity and DNA damage in vivo by treating
Trp53
(+
/
+),
Alternative Titles
Full title
The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6823306
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6823306
Other Identifiers
ISSN
0340-5761,1432-0738
E-ISSN
1432-0738
DOI
10.1007/s00204-019-02578-4
