FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leuk...
FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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FTY720 (fingolimod) is a FDA-approved sphingosine analog that is phosphorylated in vivo to modulate sphingosine-1-phosphate receptor (S1PR) signaling for immunosuppression in patients with refractory multiple sclerosis. FTY720 also exhibits promising anticancer efficacy in several preclinical models. While FTY720-induced cytotoxicity is not due to...
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FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6838108
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6838108
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-019-2080-5
