Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment...
Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection
About this item
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Author / Creator
Mullish, Benjamin H , McDonald, Julie A K , Pechlivanis, Alexandros , Allegretti, Jessica R , Kao, Dina , Barker, Grace F , Kapila, Diya , Petrof, Elaine O , Joyce, Susan A , Gahan, Cormac G M , Glegola-Madejska, Izabela , Williams, Horace R T , Holmes, Elaine , Clarke, Thomas B , Thursz, Mark R and Marchesi, Julian R
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title
Language
English
Formats
Publication information
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Subjects
More information
Scope and Contents
Contents
ObjectiveFaecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile salt hydrolases (BSHs) predisposes to CDI by perturb...
Alternative Titles
Full title
Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6839797
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6839797
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2018-317842
