Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics
Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
We engineered light-gated channelrhodopsins (ChRs) whose current strength and light sensitivity enable minimally invasive neuronal circuit interrogation. Current ChR tools applied to the mammalian brain require intracranial surgery for transgene delivery and implantation of fiber-optic cables to produce light-dependent activation of a small volume...
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Full title
Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6858556
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6858556
Other Identifiers
ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/s41592-019-0583-8
