House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation
House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs). Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neurope...
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Full title
House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6858877
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6858877
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ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/s41590-019-0493-z
