Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation o...
Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus formation. We demonstrate that induction of DSBs results in the assembly of functional promoters that include a complete RNA polymerase II preinitiation complex, MED1 and CDK9. Absence...
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Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6859070
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6859070
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ISSN
1465-7392,1476-4679
E-ISSN
1476-4679
DOI
10.1038/s41556-019-0392-4
