Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Infections by pathogens that contain DNA trigger the production of type-I interferons and inflammatory cytokines through cyclic GMP–AMP synthase, which produces 2′3′-cyclic GMP–AMP (cGAMP) that binds to and activates stimulator of interferon genes (STING; also known as TMEM173, MITA, ERIS and MPYS)
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. STING is an endoplasmic-reticu...
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Full title
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6859894
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6859894
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-0998-5
