Structural basis of STING binding with and phosphorylation by TBK1
Structural basis of STING binding with and phosphorylation by TBK1
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The invasion of mammalian cytoplasm by microbial DNA from infectious pathogens or by self DNA from the nucleus or mitochondria represents a danger signal that alerts the host immune system
1
. Cyclic GMP–AMP synthase (cGAS) is a sensor of cytoplasmic DNA that activates the type-I interferon pathway
2
. On binding to DNA, cGAS is activat...
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Full title
Structural basis of STING binding with and phosphorylation by TBK1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6862768
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6862768
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1000-2
