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MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM

MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6876235

MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM

About this item

Full title

MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2019-11, Vol.116 (47), p.23625-23635

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Myocardin-related transcription factor B (MRTFB) is a candidate tumor-suppressor gene identified in transposon mutagenesis screens of the intestine, liver, and pancreas. Using a combination of cell-based assays, in vivo tumor xenograft assays, and Mrtfb knockout mice, we demonstrate here that MRTFB is a human and mouse colorectal cancer (CRC) tumor...

Alternative Titles

Full title

MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6876235

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6876235

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1910413116

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