Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonucleas...
Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Baloxavir marboxil (BXM), an antiviral drug for influenza virus, inhibits RNA replication by binding to RNA replication cap-dependent endonuclease (CEN) of influenza A and B viruses. Although this drug was only approved by the FDA in October 2018, drug resistant viruses have already been detected from clinical trials owing to an I38 mutation of CEN...
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Full title
Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6877583
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6877583
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-53945-1
