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Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude

Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6883775

Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude

About this item

Full title

Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2019-11, Vol.116 (48), p.24006-24011

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Highland native Andeans have resided at altitude for millennia. They display high aerobic capacity (VO₂max) at altitude, which may be a reflection of genetic adaptation to hypoxia. Previous genomewide (GW) scans for natural selection have nominated Egl-9 homolog 1 gene (EGLN1) as a candidate gene. The encoded protein, EGLN1/PHD2, is an O₂ sensor th...

Alternative Titles

Full title

Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6883775

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6883775

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1906171116

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