Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma
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Author / Creator
Gryder, Berkley E. , Pomella, Silvia , Sayers, Carly , Wu, Xiaoli S. , Song, Young , Chiarella, Anna M. , Bagchi, Sukriti , Chou, Hsien-Chao , Sinniah, Ranu S. , Walton, Ashley , Wen, Xinyu , Rota, Rossella , Hathaway, Nathaniel A. , Zhao, Keji , Chen, Jiji , Vakoc, Christopher R. , Shern, Jack F. , Stanton, Benjamin Z. and Khan, Javed
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Core regulatory transcription factors (CR TFs) orchestrate the placement of super-enhancers (SEs) to activate transcription of cell-identity specifying gene networks, and are critical in promoting cancer. Here, we define the core regulatory circuitry of rhabdomyosarcoma and identify critical CR TF dependencies. These CR TFs build SEs that have the...
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Full title
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6886578
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6886578
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0534-4
