HMGB1 participates in LPS‑induced acute lung injury by activating the AIM2 inflammasome in macrophag...
HMGB1 participates in LPS‑induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF‑κB signaling pathways
About this item
Full title
Author / Creator
Wang, Jing , Li, Ruiting , Peng, Zhiyong , Hu, Bo , Rao, Xin and Li, Jianguo
Publisher
Athens: Spandidos Publications UK Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Athens: Spandidos Publications UK Ltd
Subjects
More information
Scope and Contents
Contents
High mobility group box 1 (HMGB1), a crucial proinflammatory cytokine, was reported to activate the absent in melanoma 2 (AIM2) inflammasome, which are both essential in acute lung injury (ALI). However, their interaction mechanism has remained elusive. Macrophages are known to express the AIM2 inflammasome and the main receptors [receptor for adva...
Alternative Titles
Full title
HMGB1 participates in LPS‑induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF‑κB signaling pathways
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6889921
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6889921
Other Identifiers
ISSN
1107-3756
E-ISSN
1791-244X
DOI
10.3892/ijmm.2019.4402
