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Activating mutations in CSF-1R and additional receptor tyrosine kinases in histiocytic neoplasms

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Activating mutations in CSF-1R and additional receptor tyrosine kinases in histiocytic neoplasms

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6898787

Activating mutations in CSF-1R and additional receptor tyrosine kinases in histiocytic neoplasms

About this item

Full title

Activating mutations in CSF-1R and additional receptor tyrosine kinases in histiocytic neoplasms

Author / Creator

Durham, Benjamin H. , Rodrigo, Estibaliz Lopez , Picarsic, Jennifer , Abramson, David , Rotemberg, Veronica , De Munck, Steven , Pannecoucke, Erwin , Lu, Sydney X. , Pastore, Alessandro , Yoshimi, Akihide , Mandelker, Diana , Ceyhan-Birsoy, Ozge , Ulaner, Gary A. , Walsh, Michael , Yabe, Mariko , Petrova-Drus, Kseniya , Arcila, Maria E. , Ladanyi, Marc , Solit, David B. , Berger, Michael F. , Hyman, David M. , Lacouture, Mario E. , Erickson, Caroline , Saganty, Ruth , Ki, Michelle , Dunkel, Ira J. , López, Vicente Santa-María , Mora, Jaume , Haroche, Julien , Emile, Jean-Francois , Decaux, Olivier , Geissmann, Frederic , Savvides, Savvas N. , Drilon, Alexander , Diamond, Eli L. and Abdel-Wahab, Omar

Journal title

Nature medicine, 2019-11, Vol.25 (12), p.1839-1842

Language

English

Formats

Articles

More information

Scope and Contents

Contents

Histiocytoses are clonal hematopoietic disorders frequently driven by mutations in BRAF and MEK1/2 kinases. Currently, however, the developmental origins of histiocytoses in patients are not well understood, and clinically meaningful therapeutic targets outside of BRAF and MEK are undefined. Here we uncover activating mutations in CSF-1R, as well a...

Alternative Titles

Full title

Activating mutations in CSF-1R and additional receptor tyrosine kinases in histiocytic neoplasms

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6898787

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6898787

Other Identifiers

ISSN

1078-8956

E-ISSN

1546-170X

DOI

10.1038/s41591-019-0653-6

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