Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism o...
Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Mycobacterial AdnAB is a heterodimeric helicase–nuclease that initiates homologous recombination by resecting DNA double-strand breaks (DSBs). The AdnA and AdnB subunits are each composed of an N-terminal motor domain and a C-terminal nuclease domain. Here we report cryoelectron microscopy (cryo-EM) structures of AdnAB in three functional states: i...
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Full title
Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6900545
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6900545
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1913546116
