Search-and-replace genome editing without double-strand breaks or donor DNA
Search-and-replace genome editing without double-strand breaks or donor DNA
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
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Scope and Contents
Contents
Most genetic variants that contribute to disease
1
are challenging to correct efficiently and without excess byproducts
2
,
3
,
4
–
5
. Here we describe prime editing, a versatile and precise genome editing method that directly writes new genetic information into a specified DNA site using a catalytically impaired Cas9...
Alternative Titles
Full title
Search-and-replace genome editing without double-strand breaks or donor DNA
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6907074
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6907074
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1711-4
