Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat m...
Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The use of cardiopulmonary bypass (CPB) results in the activation of leukocytes, release of neutrophil extracellular traps (NETs) and severe inflammation. We hypothesize that targeting of circulating cell-free DNA (cfDNA) by
DNases
might represent a feasible therapeutic strategy to limit CPB-associated side effects. Male Wistar rats (n = 24)...
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Full title
Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6917735
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6917735
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-55863-8
