A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis...
A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer
About this item
Full title
Author / Creator
Schmidt, Stefanie , Gay, David , Uthe, Friedrich Wilhelm , Denk, Sarah , Paauwe, Madelon , Matthes, Niels , Diefenbacher, Markus Elmar , Bryson, Sheila , Warrander, Fiona Clare , Erhard, Florian , Ade, Carsten Patrick , Baluapuri, Apoorva , Walz, Susanne , Jackstadt, Rene , Ford, Catriona , Vlachogiannis, Georgios , Valeri, Nicola , Otto, Christoph , Schülein-Völk, Christina , Maurus, Katja , Schmitz, Werner , Knight, John Raymond Philip , Wolf, Elmar , Strathdee, Douglas , Schulze, Almut , Germer, Christoph-Thomas , Rosenwald, Andreas , Sansom, Owen James , Eilers, Martin and Wiegering, Armin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Tumours depend on altered rates of protein synthesis for growth and survival, which suggests that mechanisms controlling mRNA translation may be exploitable for therapy. Here, we show that loss of APC, which occurs almost universally in colorectal tumours, strongly enhances the dependence on the translation initiation factor eIF2B5. Depletion of eI...
Alternative Titles
Full title
A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer
Authors, Artists and Contributors
Author / Creator
Gay, David
Uthe, Friedrich Wilhelm
Denk, Sarah
Paauwe, Madelon
Matthes, Niels
Diefenbacher, Markus Elmar
Bryson, Sheila
Warrander, Fiona Clare
Erhard, Florian
Ade, Carsten Patrick
Baluapuri, Apoorva
Walz, Susanne
Jackstadt, Rene
Ford, Catriona
Vlachogiannis, Georgios
Valeri, Nicola
Otto, Christoph
Schülein-Völk, Christina
Maurus, Katja
Schmitz, Werner
Knight, John Raymond Philip
Wolf, Elmar
Strathdee, Douglas
Schulze, Almut
Germer, Christoph-Thomas
Rosenwald, Andreas
Sansom, Owen James
Eilers, Martin
Wiegering, Armin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6927814
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6927814
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-019-0408-0
