Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
About this item
Full title
Author / Creator
Maglione, Marta , Kochlamazashvili, Gaga , Eisenberg, Tobias , Rácz, Bence , Michael, Eva , Toppe, David , Stumpf, Alexander , Wirth, Alexander , Zeug, André , Müller, Franziska E. , Moreno-Velasquez, Laura , Sammons, Rosanna P. , Hofer, Sebastian J. , Madeo, Frank , Maritzen, Tanja , Maier, Nikolaus , Ponimaskin, Evgeni , Schmitz, Dietmar , Haucke, Volker and Sigrist, Stephan J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective proteostasis and to protect from AMI in
Drosophi...
Alternative Titles
Full title
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
Authors, Artists and Contributors
Author / Creator
Kochlamazashvili, Gaga
Eisenberg, Tobias
Rácz, Bence
Michael, Eva
Toppe, David
Stumpf, Alexander
Wirth, Alexander
Zeug, André
Müller, Franziska E.
Moreno-Velasquez, Laura
Sammons, Rosanna P.
Hofer, Sebastian J.
Madeo, Frank
Maritzen, Tanja
Maier, Nikolaus
Ponimaskin, Evgeni
Schmitz, Dietmar
Haucke, Volker
Sigrist, Stephan J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6927957
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6927957
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-56133-3
