The effect of ligand amount, affinity and internalization on PSMA-targeted imaging and therapy: A si...
The effect of ligand amount, affinity and internalization on PSMA-targeted imaging and therapy: A simulation study using a PBPK model
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The aim of this work was to investigate the effect of ligand amount, affinity and internalization of prostate-specific membrane antigen (PSMA)-specific ligands on the activity concentrations for PET/CT imaging and on the absorbed doses for therapy. A physiologically-based pharmacokinetic (PBPK) model for PSMA-specific ligands was implemented. Thirt...
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The effect of ligand amount, affinity and internalization on PSMA-targeted imaging and therapy: A simulation study using a PBPK model
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6934468
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6934468
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-56603-8
