The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis...
The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study
About this item
Full title
Author / Creator
Hagens, Marloes H. J. , Golla, Sandeep S. V. , Janssen, Bieneke , Vugts, Danielle J. , Beaino, Wissam , Windhorst, Albert D. , O’Brien-Brown, James , Kassiou, Michael , Schuit, Robert C. , Schwarte, Lothar A. , de Vries, Helga E. , Killestein, Joep , Barkhof, Frederik , van Berckel, Bart N. M. and Lammertsma, Adriaan A.
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Purpose
The novel PET tracer [
11
C]SMW139 binds with high affinity to the P2X
7
receptor, which is expressed on pro-inflammatory microglia. The purposes of this first in-man study were to characterise pharmacokinetics of [
11
C]SMW139 in patients with active relapsing remitting multiple sclerosis (RRMS) and healthy controls (H...
Alternative Titles
Full title
The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6974509
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6974509
Other Identifiers
ISSN
1619-7070
E-ISSN
1619-7089
DOI
10.1007/s00259-019-04550-x
