Global targeting of functional tyrosines using sulfur-triazole exchange chemistry
Global targeting of functional tyrosines using sulfur-triazole exchange chemistry
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g., cysteine and lysine), a large fraction of the proteome remains inaccessible with current activity-based probes. Here, we introduce sulfur-triazole e...
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Full title
Global targeting of functional tyrosines using sulfur-triazole exchange chemistry
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6982592
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6982592
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0404-5
