Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1...
Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Poly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the
FoxO1
promoter and represses its transcription in a polymerase-indepe...
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Full title
Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6987093
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6987093
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-2265-y