Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca2+ Entry in Megakaryocytes
Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca2+ Entry in Megakaryocytes
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Author / Creator
Pelzl, Lisann , Sahu, Itishri , Ma, Ke , Heinzmann, David , Bhuyan, Abdulla Al Mamun , al-Maghout, Tamer , Sukkar, Basma , Sharma, Yamini , Marini, Irene , Rigoni, Flaviana , Artunc, Ferruh , Cao, Hang , Gutti, Ravi , Voelkl, Jakob , Pieske, Burkert , Gawaz, Meinrad , Bakchoul, Tamam and Lang, Florian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Impairment of renal phosphate elimination in chronic kidney disease (CKD) leads to enhanced plasma and tissue phosphate concentration, which in turn up-regulates transcription factor NFAT5 and serum & glucocorticoid-inducible kinase SGK1. The kinase upregulates ORAI1, a Ca
2+
-channel accomplishing store-operated Ca
2+
-entry (SOCE). OR...
Alternative Titles
Full title
Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca2+ Entry in Megakaryocytes
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6997179
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6997179
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-58384-x
