Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently
Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently
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Author / Creator
Bergmann, Sophia , von Buenau, Barbara , Vidal-y-Sy, Sabine , Haftek, Marek , Wladykowski, Ewa , Houdek, Pia , Lezius, Susanne , Duplan, Hélène , Bäsler, Katja , Dähnhardt-Pfeiffer, Stephan , Gorzelanny, Christian , Schneider, Stefan W. , Rodriguez, Elke , Stölzl, Dora , Weidinger, Stephan and Brandner, Johanna M.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The transmembrane protein claudin-1 is a major component of epidermal tight junctions (TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 downregulation has been linked to atopic dermatitis (AD) pathogenesis but variable levels of claudin-1 have also been observed in healthy skin. To elucidate the impact of different leve...
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Full title
Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7004991
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7004991
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-58718-9
