Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo
Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo
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Author / Creator
Du, Guifang , Wang, Jing , Zhang, Ting , Ding, Qiang , Jia, Xiaodong , Zhao, Xueke , Dong, Jinke , Yang, Xinrui , Lu, Shanshan , Zhang, Cuihong , Liu, Ze , Zeng, Zhen , Safadi, Rifaat , Qi, Ruizhao , Zhao, Xin , Hong, Zhixian and Lu, Yinying
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Recent studies suggest that Src family kinase (SFK) plays important roles in systemic sclerosis and pulmonary fibrosis. However, how SFKs contributed to the pathogenesis of liver fibrosis remains largely unknown. Here, we investigated the role of Fyn, a member of SFK, in hepatic stellate cell (HSC) activation and liver fibrosis, and evaluated the a...
Alternative Titles
Full title
Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7016006
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7016006
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-2229-2
