Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics
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Author / Creator
Liu, Guoxia , Papa, Arianne , Katchman, Alexander N. , Zakharov, Sergey I. , Roybal, Daniel , Hennessey, Jessica A. , Kushner, Jared , Yang, Lin , Chen, Bi-Xing , Kushnir, Alexander , Dangas, Katerina , Gygi, Steven P. , Pitt, Geoffrey S. , Colecraft, Henry M. , Ben-Johny, Manu , Kalocsay, Marian and Marx, Steven O.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic augmentation of Ca
V
1.2 voltage-gated calcium channels
1
–
4
. However, this augmentation persists in transgenic murine hearts expressing mutant Ca
V
1.2 α
1C
and β subunits that can no longer be phosphorylated by protein kin...
Alternative Titles
Full title
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7018383
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7018383
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-1947-z
