The kinase polypharmacology landscape of clinical PARP inhibitors
The kinase polypharmacology landscape of clinical PARP inhibitors
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Polypharmacology plays an important role in defining response and adverse effects of drugs. For some mechanisms, experimentally mapping polypharmacology is commonplace, although this is typically done within the same protein class. Four PARP inhibitors have been approved by the FDA as cancer therapeutics, yet a precise mechanistic rationale to guid...
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Full title
The kinase polypharmacology landscape of clinical PARP inhibitors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7026418
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7026418
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-59074-4
