UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I
UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I
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Author / Creator
Pan, Hongjie , Jiang, Ning , Sun, Shenfei , Jiang, Hanwei , Xu, Jianze , Jiang, Xiaohua , Gao, Qian , Li, Liang , Wu, Haili , Zheng, Huajun , Qi, Qi , Li, Tianqi , Zhang, Meixing , Zhang, Lingling , Wan, Xiaofeng , Lin, Xinhua , Wong, Jiemin , Shi, Qinghua and Li, Runsheng
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
5’-hydroxymethylcytosine (5hmC), an important 5’-cytosine modification, is altered highly in order in male meiotic prophase. However, the regulatory mechanism of this dynamic change and the function of 5hmC in meiosis remain largely unknown. Using a knockout mouse model, we showed that UHRF1 regulated male meiosis. UHRF1 deficiency led to failure o...
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Full title
UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7035279
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7035279
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-2333-3
