Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation
Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise a monomer or polymer of ADP-ribose (MAR or PAR, respectively) covalently attached to the acceptor residue of target proteins....
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Full title
Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7048826
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7048826
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-60631-0
