Immunization with the Gly1127-Cys1140 amino acid sequence of the LRP1 receptor reduces atheroscleros...
Immunization with the Gly1127-Cys1140 amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies
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Author / Creator
Bornachea, Olga , Benitez-Amaro, Aleyda , Vea, Angela , Nasarre, Laura , David de Gonzalo-Calvo , Escola-Gil, Juan Carlos , Cedo, Lidia , Iborra, Antoni , Martínez-Martínez, Laura , Juarez, Candido , Camara, Juan Antonio , Espinet, Carina , Borrell-Pages, Maria , Badimon, Lina , Castell, Joan and Llorente-Cortés, Vicenta
Publisher
Wyoming: Ivyspring International Publisher Pty Ltd
Journal title
Language
English
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Publisher
Wyoming: Ivyspring International Publisher Pty Ltd
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Background: The LRP1 (CR9) domain and, in particular, the sequence Gly1127-Cys1140 (P3) plays a critical role in the binding and internalization of aggregated LDL (agLDL). We aimed to evaluate whether immunization with P3 reduces high-fat diet (HFD)-induced atherosclerosis. Methods: Female New Zealand White (NZW) rabbits were immunized with a prima...
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Full title
Immunization with the Gly1127-Cys1140 amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7053206
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7053206
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ISSN
1838-7640
E-ISSN
1838-7640
DOI
10.7150/thno.37305
