Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation
Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its mechanism in initiating distant metastasis is not well understood. Here, we generated a novel conditional allele of
Cxcl12
in mice and used a fibroblast-specific
Cre
transgene along with various mammary tumor models to evaluate CXCL12 function in the breas...
Alternative Titles
Full title
Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7063845
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7063845
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-018-0263-7
