Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus
Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus
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Author / Creator
Smith, Michael A. , Chiang, Chia-Chien , Zerrouki, Kamelia , Rahman, Saifur , White, Wendy I. , Streicher, Katie , Rees, William A. , Schiffenbauer, Adam , Rider, Lisa G. , Miller, Frederick W. , Manna, Zerai , Hasni, Sarfaraz , Kaplan, Mariana J. , Siegel, Richard , Sinibaldi, Dominic , Sanjuan, Miguel A. and Casey, Kerry A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Type I interferon (IFN) drives pathology in systemic lupus erythematosus (SLE) and can be tracked via IFN-inducible transcripts in blood. Here, we examined whether measurement of circulating proteins, which enter the bloodstream from inflamed tissues, also offers insight into global IFN activity. Using a novel protocol we generated 1,132 aptamer-ba...
Alternative Titles
Full title
Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7064569
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7064569
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-60563-9
