Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin...
Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Reelin is a secreted protein that plays versatile roles in neuronal development and function. The strength of Reelin signaling is regulated by proteolytic processing, but its importance
in vivo
is not yet fully understood. Here, we generated Reelin knock-in (PA-DV KI) mice in which the key cleavage site of Reelin was abolished by mutation. As...
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Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7066138
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7066138
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-61380-w
