Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associa...
Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Dysregulation of the mammalian target of rapamycin (mTOR) signaling, which is mediated by two structurally and functionally distinct complexes, mTORC1 and mTORC2, has been implicated in several neurological disorders
1
–
3
. Individuals carrying loss-of-function mutations in the phosphatase and tensin homolog (
PTEN
) gene, a nega...
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Full title
Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7082835
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7082835
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-019-0608-y
