Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8⁺ T cell stemness and antitumor...
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8⁺ T cell stemness and antitumor immunity
About this item
Full title
Author / Creator
Hermans, Dalton , Gautam, Sanjivan , García-Cañaveras, Juan C. , Gromer, Daniel , Mitra, Suman , Spolski, Rosanne , Li, Peng , Christensen, Stephen , Nguyen, Rosa , Lin, Jian-Xin , Oh, Jangsuk , Du, Ning , Veenbergen, Sharon , Fioravanti, Jessica , Ebina-Shibuya, Risa , Bleck, Christopher , Neckers, Leonard M. , Rabinowitz, Joshua D. , Gattinoni, Luca and Leonard, Warren J.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Interleukin (IL)-2 and IL-21 dichotomously shape CD8⁺ T cell differentiation. IL-2 drives terminal differentiation, generating cells that are poorly effective against tumors, whereas IL-21 promotes stem cell memory T cells (TSCM) and antitumor responses. Here we investigated the role of metabolic programming in the developmental differences induced...
Alternative Titles
Full title
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8⁺ T cell stemness and antitumor immunity
Authors, Artists and Contributors
Author / Creator
Gautam, Sanjivan
García-Cañaveras, Juan C.
Gromer, Daniel
Mitra, Suman
Spolski, Rosanne
Li, Peng
Christensen, Stephen
Nguyen, Rosa
Lin, Jian-Xin
Oh, Jangsuk
Du, Ning
Veenbergen, Sharon
Fioravanti, Jessica
Ebina-Shibuya, Risa
Bleck, Christopher
Neckers, Leonard M.
Rabinowitz, Joshua D.
Gattinoni, Luca
Leonard, Warren J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7084161
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7084161
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1920413117
