HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The anti-cancer drug target poly(ADP-ribose) polymerase 1 (PARP1) and its close homologue, PARP2, are early responders to DNA damage in human cells
1
,
2
. After binding to genomic lesions, these enzymes use NAD
+
to modify numerous proteins with mono- and poly(ADP-ribose) signals that are important for the subsequent decompaction...
Alternative Titles
Full title
HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7104379
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7104379
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2013-6
